QO1 (UVIGO)

Datos de Contacto


Teléfono: (+34) 986 812316

Fax: (+34) 986 818622

Dirección:
Campus en Lagoas Marcosende
36310
Vigo.

Imágen Sede





Información General Organización

El grupo QO1 de la Universidade de Vigo trabaja fundamentalmente en las siguientes líneas de investigación:

  • química y biología de retinoides
  • síntesis estereocontrolada de carotenoides y polienos relacionados
  • diseƱo y síntesis de moduladores epigenéticos basados en productos naturales;
  • análisis computacional de reacciones pericíclicas;
  • análisis computacional de procesos catalíticos organometálicos.

 

Organización


Nombre oficial de la organización: Universidad de Vigo.

Titularidad de la organización: Pública.

Denominación del grupo: QO1.

Investigador Responsable: Angel Rodríguez de Lera.

Persona de contacto: Angel Rodríguez de Lera.

Página web: http://webs.uvigo.es/delera

Datos Infraestructuras

Capacidades disponibles:

  • HPLC-ESI Waters, Waters Premier liquid chromatograph coupled time-of-flight mass spectrometer.
  • HPLC/MS-TOF) with electrospray ionization (ESI), In situ FTIR Reaction Analysis (Mettler-Toledo).
  • Varian/Analogix IntelliFlash 310, Flash Chromatography System.
  • Microwave Reactor Explorer CEM.
  • MiniMapper, liquid handling and synthesis (Mettler-Toledo).
  • UV-Visible (CARY 200) spectrophotometer.
  • Polarimeter Jasco P-1020.
  • HPLC Waters.
  • HPFC Horyzon (Biotage) (High Performance Flash Chromatography).
  • Personal evaporator EZ-2 (Genevac).
  • FTIR (Jasco 4200).
  • NMR 400 MHz (Bruker).
  • Solvent purification system Pure Solv 400.
  • Microwave Discover SP-D CEM, Intelligent Rack Design.

Personal


Personal fijo

Número Doctores: 5.

Número Licenciados: 0.

Número Técnicos: 0.

Número Ótro Personal: 0.


Personal Contratado

Número Doctores: 6.

Número Licenciados: 5.

Número Técnicos: 0.

Ótro Personal : 1 (gestor).


Capacidades Disponibles


  • 1. Chemistry and Biology of Retinoids
  • "Chemical mutagenesis" of retinal(ol) to provide tools for biological evaluation through stereoselective palladium-catalyzed cross-coupling reactions. These analogues are then used on collaborations to help understand:
    • Retinal and retinoid metabolism.
    • Vision in vertebrates.
    • Bacterial photopigments.
    • Nuclear receptor biology through the design and synthesis of selective modulators.
  • 2. Stereocontrolled Synthesis of Carotenoids and Related Polyenes
  • Convergent approaches to both the side-chain and the rings of complex carotenoids decorated with functional groups and stereocenters including allene axis.
  • 3. Design and Synthesis of Epigenetic Modulators Based on Natural Products
  • Development of novel epigenetic drugs targeting HDACs, HATs, PRMTs and DNMTs using two structure-based general approaches to drug design and development: a) virtual ligand screening (VLS) of large libraries of drug-like molecules following modeling of the receptor-ligand interaction complexes and selection of leads; b) focused-library development of libraries based on VS or in privileged structures inspired in natural products already reported as epigenetic modulators.
  • 4. Tandem Organometallic Catalytic Processes for generation of diversity and complexity.





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