Nombre oficial de la organización: Universidad de Vigo.

Titularidad de la organización: Pública.

Denominación del grupo: QO1.

Investigador Responsable: Angel Rodríguez de Lera.

Persona de contacto: Angel Rodríguez de Lera.

Página web: http://webs.uvigo.es/delera

Capacidades disponibles:

• HPLC-ESI Waters, Waters Premier liquid chromatograph coupled time-of-flight mass spectrometer.
• HPLC/MS-TOF) with electrospray ionization (ESI), In situ FTIR Reaction Analysis (Mettler-Toledo).
• Varian/Analogix IntelliFlash 310, Flash Chromatography System.
• Microwave Reactor Explorer CEM.
• MiniMapper, liquid handling and synthesis (Mettler-Toledo).
• UV-Visible (CARY 200) spectrophotometer.
• Polarimeter Jasco P-1020.
• HPLC Waters.
• HPFC Horyzon (Biotage) (High Performance Flash Chromatography).
• Personal evaporator EZ-2 (Genevac).
• FTIR (Jasco 4200).
• NMR 400 MHz (Bruker).
• Solvent purification system Pure Solv 400.
• Microwave Discover SP-D CEM, Intelligent Rack Design.

Personal fijo

Número Doctores: 5.

Número Licenciados: 0.

Número Técnicos: 0.

Número Ótro Personal: 0.

Personal Contratado

Número Doctores: 6.

Número Licenciados: 5.

Número Técnicos: 0.

Ótro Personal : 1 (gestor).

• 1. Chemistry and Biology of Retinoids
"Chemical mutagenesis" of retinal(ol) to provide tools for biological evaluation through stereoselective palladium-catalyzed cross-coupling reactions. These analogues are then used on collaborations to help understand:
• Retinal and retinoid metabolism.
• Vision in vertebrates.
• Bacterial photopigments.
• Nuclear receptor biology through the design and synthesis of selective modulators.
• 2. Stereocontrolled Synthesis of Carotenoids and Related Polyenes
Convergent approaches to both the side-chain and the rings of complex carotenoids decorated with functional groups and stereocenters including allene axis.
• 3. Design and Synthesis of Epigenetic Modulators Based on Natural Products
Development of novel epigenetic drugs targeting HDACs, HATs, PRMTs and DNMTs using two structure-based general approaches to drug design and development: a) virtual ligand screening (VLS) of large libraries of drug-like molecules following modeling of the receptor-ligand interaction complexes and selection of leads; b) focused-library development of libraries based on VS or in privileged structures inspired in natural products already reported as epigenetic modulators.
• 4. Tandem Organometallic Catalytic Processes for generation of diversity and complexity.